(AP) Buffalo running backs C.J. Spiller and Fred Jackson will both play Thursday night against the Browns after being slowed by injuries.
Jackson, who leads the Bills with 256 rushing yards and two touchdowns, sprained his left knee last week in a win over Baltimore and will wear a brace. Spiller sprained his ankle in the third quarter against the Ravens and returned to practice Wednesday after missing the two previous days.
Last season against Cleveland, Spiller went out with a shoulder injury in the first half and third-stringer Tashard Choice ran for 91 yards in Buffalo's 24-14 win.
Also, the Bills will be without starting cornerback Stephon Williams and free safety Jairus Byrd.
Browns quarterback Brandon Weeden will back up starter Brian Hoyer. Weeden sprained his thumb in Week 2 and Hoyer is 2-0 in two starts. Jason Campbell is inactive.