EAST RUTHERFORD, N.J. — Eli Manning came up with a near-record performance in throwing for 510 yards, and Andre Brown scored on a 2-yard run with 31 seconds left to lift the New York Giants to a wild 41-34 victory Sunday over the Tampa Bay Buccaneers.
Manning's yardage total was the second most for a Giants quarterback, and tied for the eighth highest in NFL history.
He threw three first-half interceptions, and came back with a monster 295 yards passing in the second, finishing 3 yards short of Phil Simms' team record.
The Bucs (1-1) led by 11 points before the Super Bowl champions came back and avoided an 0-2 start.
Manning threw touchdowns of 23 yards to Hakeem Nicks, 80 to Victor Cruz and 33 to Martellus Bennett with 3:59 to play to give New York a 34-27 lead.
Cruz finished with 11 catches for 179 yards, both career highs, while Nicks had 10 catches for 199 yards, with the yardage a personal best. Only the 1951 Rams had a 500-yard passer and two 150-yard receivers in the same game.
Josh Freeman tied the game at 34-all with a 41-yard pass to Mike Williams, but Manning drove New York 80 yards in four plays to win it.
SAN FRANCISCO — San Francisco's stingy defense denied Matthew Stafford another milestone, Vernon Davis caught touchdown passes of 21 and 23 yards from Alex Smith, and the 49ers beat Detroit.
Smith completed 20 of 31 throws for 226 yards and extended his franchise-record streak of passes without an interception to 216, leading the NFC West favorite Niners (2-0) to their ninth straight win in the series. Smith took a hard hand to the helmet from John Wendling late and bloodied his nose.
FOXBOROUGH, Mass. — Backup quarterback Kevin Kolb threw for one touchdown and ran for another, Stephen Gostkowski missed a potential winning field goal in the final seconds, and Arizona moved to 2-0.
The Patriots took over when Vince Wilfork recovered a fumble at the Cardinals 30 with 1:01 left. A 30-yard run into the end zone by Danny Woodhead was nullified by a holding penalty against Rob Gronkowski. New England then moved to the 24 before Tom Brady spiked the ball to stop the clock with 6 seconds left, but Gostkowski sent a 42-yard try wide to the left after hitting four earlier field goals.
CHARLOTTE, N.C. — Cam Newton threw for 253 yards and ran for a career-high 71 yards to hand New Orleans its first 0-2 start since 2007.
One week after tying a franchise low with 10 yards rushing in a loss to Tampa Bay, the Panthers ran for 219 yards and Newton, DeAngelo Williams and Mike Tolbert all scored on short touchdown runs. Steve Smith overcame a sore knee to finish with 104 yards receiving — the 39th 100-yard receiving game of his career — and Jonathan Stewart hauled in a 17-yard touchdown reception for the Panthers (1-1).
INDIANAPOLIS — Adam Vinatieri made a 53-yard field goal with 8 seconds left to give Andrew Luck his first NFL victory.
Minnesota (1-1) rallied from a two-touchdown deficit in the final 5 1/2 minutes and tied the score on a 6-yard TD pass from Christian Ponder to Kyle Rudolph with 31 seconds left.
MIAMI — Reggie Bush ran for 172 yards and two touchdowns, and Miami won a home opener for the first time since 2005.
Ryan Tannehill threw his first NFL touchdown pass, ran for another and avoided any turnovers after tossing three interceptions in his pro debut a week earlier.
ST. LOUIS — Sam Bradford threw for 310 yards and three touchdowns and Danny Amendola caught 15 passes for 160 yards in rallying St. Louis
Robert Griffin III led the Redskins (1-1) to a 21-6 lead, but the Rams (1-1) came back thanks to the pass-catching of Amendola. The receiver tied an NFL record 12 first-half receptions, and caught a 1-yard TD pass to cut the lead to 21-13 at the half.
SEATTLE — Marshawn Lynch ran for 122 yards and a 3-yard touchdown in the fourth quarter and Seattle's special teams came up with two huge first-quarter plays that led to 10 points.
Michael Robinson forced Felix Jones to fumble on the opening kickoff that led to a short field goal, and Malcolm Smith blocked Chris Jones' punt which Jeron Johnson returned for a touchdown to give Seattle (1-1) a 10-0 lead in less than 5 minutes.
SAN DIEGO — Tight end Dante Rosario had three touchdown catches for the first time in his NFL career and San Diego's defense harassed Jake Locker all day.
Before the game, the Chargers (2-0) retired Junior Seau's No. 55. Seau, the hard-hitting, first-pumping leader of the Chargers for 13 seasons, committed suicide May 2.
CINCINNATI — Adam "Pacman" Jones returned Cleveland's first punt 81 yards for a touchdown, and Andy Dalton matched his career high with three touchdown passes.
ORCHARD PARK, N.Y. — C.J. Spiller scored twice and had 123 yards rushing in sparking Buffalo.
JACKSONVILLE, Fla. — Arian Foster ran for 110 yards and a touchdown, Ben Tate added 74 yards and two scores and Houston dominated from the start.