EAST RUTHERFORD, N.J. — Eli Manning threw for three touchdowns, giving him 200 for his career, and the New York Giants sacked Aaron Rodgers five times Sunday night in a 38-10 rout of the Green Bay Packers.
Coming off their bye, the Giants (7-4) put to rest concerns about a dormant offense and a tired arm for Manning. He connected with rookie Rueben Randle, Victor Cruz and Hakeem Nicks for scores, and Ahmad Bradshaw had a combined 119 yards, including a 59-yard sprint on a screen pass to begin the onslaught.
The Giants opened a two-game lead in the NFC East.
TAMPA, Fla. — Matt Ryan threw for 353 yards and overcame two big turnovers by leading another late touchdown drive to give the Atlanta Falcons a victory over the Tampa Bay Buccaneers.
Ryan teamed with Julio Jones on an 80-yard TD in the third quarter, but the NFC South leaders found themselves trailing 23-17 after the Bucs marched for a touchdown, then forced a fumble by Ryan to set up a field goal that put the Falcons in catchup mode.
KANSAS CITY, Mo. — Peyton Manning threw for 285 yards and two touchdowns, and Denver rallied for its sixth straight win.
Manning hit tight end Jacob Tamme late in the first half and wide receiver Demaryius Thomas in the third quarter, and that was more than enough to overcome three field goals by the Chiefs' Ryan Succop as Kansas City lost its eighth straight game.
CHICAGO — Jay Cutler threw for 188 yards and a touchdown after missing a game because of a concussion as Chicago ended a two-game losing streak.
Tied with Green Bay for the NFC North lead and just a game ahead of Minnesota (6-5) coming in, the Bears (8-3) grabbed a 25-3 halftime lead thanks to Cutler's pinpoint passing. The defense held Adrian Peterson in check early on, although he finished with 108 yards rushing.
NEW ORLEANS — Colin Kaepernick ran for one score that he made look easy and threw for a touchdown in another performance that validated coach Jim Harbaugh's decision to start him.
The San Francisco defense added its share of big plays and the 49ers ended the Saints' three-game winning streak.
Ahmad Brooks and Donte Whitner each returned interceptions for touchdowns and the 49ers sacked Brees five times.
SAN DIEGO — Justin Tucker kicked a 38-yard field with 1:07 left in overtime to complete a stunning comeback.
San Diego led 13-3 on Nick Novak's 30-yard field goal with 7:51 to go in regulation and seemed headed for its first win against a team with a winning record this season.
But the Ravens converted on fourth-and-29 from their 37 when Ray Rice caught a short pass from Joe Flacco and weaved through the defense to the San Diego 33 with 1:37 to play. After a review, the ball was moved back to the 34 and the refs measured. The new spot gave the Ravens a first down by the length of the ball.
GLENDALE, Ariz. — Janoris Jenkins became the first player in Rams history and the first NFL rookie since 1960 to return two interceptions for touchdowns in the same game and St. Louis dominated the second half to hand the Arizona Cardinals their seventh loss in a row, 31-17 on Sunday.
Arizona rookie Ryan Lindley was intercepted four times in his first NFL start.
Jenkins' returns of 36 and 39 yards emphatically ended the Rams' streak of five straight games without an opponent turnover.
CINCINNATI — Andy Dalton threw three touchdown passes and Cincinnati showed its former quarterback, Carson Palmer, that it has moved on without him.
BenJarvus Green-Ellis ran for 129 yards and a touchdown against the NFL's most generous defense. He had runs of 48 and 39 yards — the longest of his career — to set up scores.
Palmer had a tough time all-around in his return to Cincinnati, going 19 of 34 for 146 yards with four sacks and an interception.
INDIANAPOLIS — T.Y. Hilton scored on a 75-yard punt return and caught an 8-yard TD pass from Andrew Luck.
Hilton is the first player in franchise history to score by punt return and pass reception in the same game. Indy improved to 7-4.
JACKSONVILLE, Fla. — Chad Henne threw two touchdown passes, sparking the NFL's worst offense for the second consecutive week.
The Jaguars (2-9) snapped a seven-game losing streak and were competitive at home for the first time this season.
Henne, making his first start in more than 13 months, found Cecil Shorts III on a 59-yard touchdown play in the third quarter and hooked up with rookie Justin Blackmon for a 7-yard score in the fourth.
MIAMI — Dan Carpenter kicked a 43-yard field goal on the final, and Miami scored 17 points in the last 8:08.
Rookie Ryan Tannehill drove Miami 65 yards in the final 92 seconds to set up the winning kick. He finished 18 for 26 for 253 yards and a score.
Leon Washington returned a kickoff for a touchdown for the eighth time to tie the NFL career record and put Seattle ahead with eight minutes left. Miami answered with an 80-yard drive capped by Tannehill's 29-yard scoring pass to Charles Clay, making it 21-all.