Democratic presidential candidate former Vice President Joe Biden enters a campaign event in Columbus, Ohio on Tuesday. 
                                 Paul Vernon | AP photo

Democratic presidential candidate former Vice President Joe Biden enters a campaign event in Columbus, Ohio on Tuesday.

Paul Vernon | AP photo

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Joe Biden won the Michigan primary and two other states Tuesday, cementing his status atop the Democratic field and raising calls for Bernie Sanders to stand aside and begin the process of unifying the party to face President Donald Trump in November.

On a roll since taking command of the race last week, Biden also racked up victories in Missouri and Mississippi, padding his delegate lead over Vermont’s senator and lengthening the odds of a Sanders comeback.

“The race for all intents and purposes was over last Tuesday. Michigan confirms it,” said Paul Maslin, a veteran Democratic strategist who is neutral in this year’s nominating fight. “The primaries in the rest of March will make it mathematically certain.”

Others, on different ends of the Democratic Party spectrum, echoed the sentiment.

South Carolina Rep. James E. Clyburn, whose endorsement was instrumental in launching Biden to victory in his home state — a win that changed the course of the race overnight — said on NPR that it was time to “shut this primary down,” starting with the cancellation of a debate scheduled for Sunday in Phoenix.

Guy Cecil, the head of Priorities USA, a major Democratic political action committee, said “the math is now clear” and announced the organization would throw its considerable weight behind Biden.

On the left, Ilya Sheyman, former head of the progressive political group MoveOn, sent “love and care” to Sanders and his campaign even as he signaled his belief the Democratic race was over.

“We need unity in Nov. to stop Trump, win Senate & build future,” he wrote on Twitter.

On a day when concerns over the spreading coronavirus shadowed the campaign, primaries and caucuses were also held in North Dakota, Idaho and Washington state.

The balloting was modest compared with last week’s 15-contest Super Tuesday extravaganza. A mere 356 pledged delegates were at stake, compared with nearly 1,400 a week ago.

Still, the outcome in the six contests seemed likely to significantly shape the campaign going forward.

The vote came as the two candidates were moving in opposite directions:

The former vice president was on the ascent, showered with millions of dollars in contributions and bolstered by dozens of fresh endorsements after his 10 Super Tuesday victories. (He picked up another Tuesday night, erstwhile opponent Andrew Yang.)

Sanders was struggling to overcome Biden’s growing momentum as well as delegate math that makes his path to the White House increasingly steep.

Biden entered the day with 664 pledged delegates to Sanders’ 573, according to The Associated Press. It takes 1,991 delegates to win the nomination on the first ballot at the Democrats’ July convention and Biden’s strong showing in several states suggested that his lead over Sanders would grow substantially.

Before the polls closed, Sanders and Biden announced they were canceling election night rallies scheduled in Cleveland ahead of next week’s Ohio primary. Biden planned to speak instead at the National Constitution Center in Philadelphia, where his campaign is headquartered.

Both camps cited concerns from public health officials about the possible spread of the coronavirus within the large crowds the two candidates have been attracting.

“All future Bernie 2020 events will be evaluated on a case-by-case basis,” a spokesman said.

Similarly, the Biden campaign said it would “continue to consult with public health officials … and make announcements about future events.”

A freeze on campaigning could further undermine Sanders’ hopes to rally against Biden, said Stuart Rothenberg, an independent campaign analyst. “Without those enthusiastic rallies, it’s hard to see how Bernie changes the trajectory of the Democratic contest,” Rothenberg said.

“The Democratic race is over,” he added. “The only question is whether Bernie Sanders knows it and admits it.”

Of Tuesday’s contests, Michigan appeared to be the most important, offering the largest share of delegates — 125 — and carrying important symbolic overtones.

Sanders won the state four years ago, a victory that sparked his campaign just as Hillary Clinton seemed about to wrap up the nomination, and his emphasis on working-class issues seemed especially well tailored to a large blue-collar electorate that has faced years of industrial decline and massive job losses to low-wage countries. He canceled appearances in three other states to spend more time in Michigan, a move that underscored its political import.

As he did in 2016, Sanders focused on trade, attacking Biden for his support of the North American Free Trade Agreement while serving in the Senate in the 1990s. Sanders raised the issue in two TV spots, one featuring an autoworker who said his community “has been decimated by trade deals” and lumping Biden together with Trump.

But those attacks seemed to gain little purchase against Biden, who ran strongly among Michigan voters across the board: black and white, those with college degrees and without, city dwellers as well as suburbanites.

Elsewhere, Mississippi and Missouri had both appeared promising for Biden, given their respective political makeups.

In Missouri, more than three-quarters of those who voted Tuesday said they were moderate or only “somewhat” liberal, words that could be used to describe Biden.

In Mississippi, the former vice president prevailed on the strength of overwhelming black support, repeating the pattern that carried him to victory Feb. 29 in South Carolina — the performance that resuscitated his flagging campaign — and helped him capture five more states across the South on Super Tuesday.

African Americans made up nearly two-thirds of the Mississippi electorate, and more than 8 in 10 voted for Biden.

Repeating another pattern seen nationwide, the majority of voters in Michigan, Mississippi and Missouri said their top priority was choosing a candidate who could beat Trump in November, rather than one who agreed with them on issues. They voted in much greater number for Biden over Sanders, as they have in most other states.

The Vermont senator was hoping for repeat wins in Idaho and Washington, which he easily carried in 2016.

Both were caucus states then. This year they are holding primaries under a rules change supported by Sanders in hopes of boosting voter participation.