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CLEMSON, S.C. (AP) — Trevor Lawrence threw two touchdown passes, Travis Etienne ran for three scores and Clemson shook off a sluggish performance to win its 27th straight Atlantic Coast Conference game and put away pesky Syracuse.

The Tigers opened 6-0 for the sixth straight season, but it took a late burst to get it done — just like usual against Syracuse (1-5, 1-4). The Orange were the last ACC team to beat the Tigers (5-0 ACC) with a 27-24 victory in 2017. A year later at Death Valley, Syracuse again looked primed for the upset as it held a 10-point lead in the fourth quarter before Clemson’s 27-23 escape to keep its national championship season intact. Syracuse kept the Tigers out of synch much of the game and was down just 27-21 late in the third quarter. But Andrew Booth Jr.’s fumble recovery and touchdown run after Rex Culpepper was sacked late in the third quarter turned the game in Clemson’s favor for good. Etienne added rushing TDs of 9 and 1 yard. Lawrence threw for 289 yards with scoring passes of 25 yards to Cornell Powell and 18 yards to Davis Allen. The Tigers broke fast for a 17-0 lead less than 11 minutes into the game. That’s when things got away from the five-time defending ACC champion. Syracuse freshman Drew Tuazama blocked a punt and four plays later Sean Tucker scored on a 7-yard run. Then right before half, Orange cornerback Garrett Williams caught a pass off Amari Rodgers’ hands and took it 39 yards for a pick six. Syracuse made it a one-score game when Nykeim Johnson caught an 83-yard TD pass from Culpepper to draw to 27-21 — and stun the crowd of about 19,000 before Booth’s defensive score got the Tigers rolling to victory. NO. 2 ALABAMA 48, TENNESSEE 17

KNOXVILLE, Tenn. (AP) — Mac Jones threw for 387 yards and ran for a touchdown, and Najee Harris ran for three more scortes to help Alabama rout Tennessee for its 14th straight win in the rivalry. The Crimson Tide (5-0) outgained Tennessee 587-302. But playing the Vols proved costly for Alabama a second straight season. A year ago, Tua Tagovailoa hurt an ankle in the second quarter and missed the next game against Arkansas.

On Saturday, Waddle rolled his right ankle as he was tackled on the opening kickoff and was taken by cart to the locker room. Alabama coach Nick Saban said Waddle had a high ankle sprain with a fracture that probably will need surgery. Tennessee (2-3) forced Alabama to punt on its opening drive. That was as close as the Vols would get in losing their seventh straight in this series in Neyland Stadium.

NO. 3 NOTRE DAME 45, PITTSBURGH 3

PITTSBURGH (AP) — Ian Book passed for 312 yards and three touchdowns — two of them long catch-and-runs to graduate transfer Ben Skowronek — and Notre Dame overwhelmed reeling Pittsburgh.

A week after scuffling its way past Louisville, Notre Dame (5-0, 4-0 Atlantic Coast Conference) had no such issues while handling the Panthers (3-4, 2-4) their fourth consecutive loss.

Book hit Skowronek for a 34-yard score on Fighting Irish’s first possession and Pitt — playing without injured senior quarterback Kenny Pickett for a second straight week — simply could not keep up.

Notre Dame’s massive offensive line held its own against one of the nation’s best pass-rushing teams and when Book had time, he had no trouble finding teammates open downfield. Book averaged 19.5 yards per completion and often had to do little more than flip the ball up and let his playmakers do the rest. He connected with Skowronek for a 73-yard score in the second quarter, with the 6-foot-3 Skowronek doing most of the work as he out-jumped 5-9 Pitt defensive back Marquis Williams for the ball then sprinted to the end zone to make it 14-3.

NO. 5 OHIO STATE 51, NEBRASKA 17

COLUMBUS, Ohio (AP) — Justin Fields completed 20 of 21 passes for two touchdowns and ran for another score, Master Teague III rushed for a pair of scores and Ohio State rolled over Nebraska in the Big Ten teams’ pandemic-delayed opener.

Fields completed his first 12 passes and threw for 276 yards. He ran for another 52 yards — including a stunning 17-yard third-quarter touchdown scramble around the left side that saw him spin past a defender into the end zone. The Ohio State defense took most of the first half to figure out a way to contain quarterback Adrian Martinez, who marched the Huskers down for a touchdown in the opening 2 minutes of the game.

Nebraska tied it at 14 in the second quarter, but Ohio State had a field goal, a defensive stop and Teague’s second TD run to lead 24-14 at the half. Then came Fields’ nifty touchdown run and a 55-yard scoop and score by Buckeyes cornerback Sevyn Banks, and Ohio State had it under control. NO. 6 OKLAHOMA STATE 24, NO. 17 IOWA STATE 21

STILLWATER, Okla. (AP) — Spencer Sanders passed for 235 yards and ran for 71 and a touchdown in his return from injury and Oklahoma State beat Iowa State.

Sanders had been out since injuring his right ankle in the season-opener against Tulsa.

Chuba Hubbard ran for 139 yards and a touchdown to help Oklahoma State (4-0, 3-0 Big 12) join Kansas State as the only remaining undefeated teams in conference play.

The Cyclones (3-2, 3-1) vaulted onto the national radar by beating Oklahoma in the month and were seeking their first ever 4-0 start in league play. Iowa State’s Breece Hall, who was second nationally in yards rushing per game, ran for a career-high 185 yards.

NO. 9 CINCINNATI 42, NO. 16 SMU 13

DALLAS (AP) — Desmond Ridder ran for 179 yards and three touchdowns and threw for 126 yards and a score to help Cincinnati beat SMU in a showdown of unbeaten teams. Cincinnati (4-0, 2-0 American) played its first game since Oct. 3. The Bearcats had an open date the following weekend and then had their scheduled Oct. 17 home game against Tulsa moved to Dec. 5 because of positive COVID-19 cases at Cincinnati and the quarantining of athletes at the school.

Ridder completed 13 of 21 passes. He had scoring runs of 15, 32 and 91 yards, and threw a 7-yard touchdown pass to Josh Whyle to open the scoring.

Gerrid Doaks ran for 105 yards on 20 carries, with touchdown runs of 1 and 35 yards.

Shane Buechele threw a 9-yard touchdown pass to Rashee Rice, and Chris Naggar kicked field goals of 26 and 22 yards for SMU (5-1, 2-1). The Mustangs fell short of opening with six straight wins for the second straight season.

THE TAKEAWAY

NO. 11 MIAMI 19, VIRGINIA 14

MIAMI GARDENS, Fla. (AP) — D’Eriq King threw for 322 yards and a touchdown, Mike Harley had career bests of 10 catches for 170 yards and Miami outlasted Virginia.

Harley’s big night for Miami (5-1, 4-1 Atlantic Coast Conference) started with a 43-yard touchdown grab on the Hurricanes’ second play from scrimmage. King completed his first nine passes and finished 21 for 30. Don Chaney had a 1-yard rushing touchdown in the fourth for Miami.

Brennan Armstrong, back in the lineup after missing a game with a concussion, completed 16 of 30 passes for 180 yards and two touchdowns for Virginia (1-4, 1-4). It was the fourth straight loss for the Cavaliers, and this marks the first time since 2013 that they’ve played four consecutive games without ever holding a lead. Armstrong also ran for 91 yards.

NO. 14 NORTH CAROLINA 48, NO. 23 NORTH CAROLINA STATE 21

CHAPEL HILL, N.C. (AP) — Javonte Williams ran for 160 yards and three touchdowns and North Carolina beat North Carolina State in the renewal of the longtime state rivalry.

Michael Carter ran for 106 yards and a score of his own for the Tar Heels (4-1, 4-1 Atlantic Coast Conference), who used a run-through-and-over-tacklers ground game that helped them take control in the third quarter. UNC ran for 326 yards and finished with 578 overall, bouncing back from an upset loss at Florida State to beat the Wolfpack (4-2, 4-2).

Sam Howell threw for 252 yards and a TD for the Tar Heels, while Dyami Brown had 105 yards on a career-best seven catches.

NO. 18 MICHIGAN 49, NO. 21 MINNESOTA 24

MINNEAPOLIS (AP) — Joe Milton accounted for two touchdowns in an unflappable debut at quarterback for No. 18 Michigan, and the Wolverines trampled with 258 yards rushing to open the virus-delayed season.

Zach Charbonnet had a 70-yard scoring run in the first quarter to set the tone for Michigan’s dominance on offense, one of five rushing touchdowns. Donovan Jeter followed by scoring on a 15-yard scoop of an airborne fumble forced by a blitzing Michael Barrett, one of five sacks by the Wolverines.

Barrett added a 66-yard kickoff return to set up Milton’s scoring pass to Ben Mason that capped a 21-point first quarter to spur the Wolverines to their 13th win in the last 15 conference openers. They have not lost at Minnesota in the battle for the Little Brown Jug trophy since 1977. Minnesota’s Tanner Morgan passed for 188 yards and a touchdown, with two turnovers.

WAKE FOREST 23, NO. 19 VIRGINIA TECH 16

WINSTON-SALEM, N.C. (AP) — Walk-on freshman safety Nick Andersen had three interceptions, Christian Beal-Smith ran for 129 yards and Nick Sciba kicked three field goals to help Wake Forest beat Virginia Tech.

Andersen stopped two deep Hokies drives and the third ended their final possession.

Beal-Smith set the tone for the Demon Deacons (3-2, 2-2 Atlantic Coast Conference) with a 58-yard run on the game’s first series. He later added runs of 26 and 19 yards.

Wake Forest quarterback Sam Hartman threw only 17 times, completing 12 for 110 yards. But he scrambled 9 yards for the game’s first score. Hendon Hooker threw for 223 yards and ran for another 98 for the Hokies (3-2, 3-2). They had won six of the previous seven games between the schools.

NO. 20 KANSAS STATE 55, KANSAS 14

MANHATTAN, Kan. (AP) — Phillip Brooks returned a pair of punts for touchdowns, Kansas State took advantage of an embarrassing day of special teams by its biggest rival, and the Wildcats rolled past Kansas,

Will Howard threw for 243 yards and two touchdowns while Justin Gardner returned an interception 25 yards for another score, helping the Wildcats (4-1) improve to 4-0 in the Big 12 for the first time since 2014. Deuce Vaughn added 71 yards rushing and another touchdown as Kansas State beat the Jayhawks (0-5, 0-4) for a series-record 12th straight time. Kansas has not beaten its Interstate 70 rival since Nov. 1, 2008, in Lawrence. The Jayhawks were playing their first game since coach Les Miles returned from a positive COVID-19 test.

NO. 22 MARSHALL 20, FLORIDA ATLANTIC 9

HUNTINGTON, W.Va. (AP) — Brenden Knox rushed for 101 yards and caught one of redshirt freshman Grant Wells’ two touchdown passes to lead Marshall over pandemic-depleted Florida Atlantic.

Marshall (5-0, 3-0 Conference USA) managed enough offense to hold off the pesky Owls (1-1, 1-1).

FAU brought 57 players on its first trip of the season, just above the mandated minimum of 53 available scholarship players during the pandemic. The Owls even held a third-quarter lead before Marshall scored the final 13 points. With FAU missing both of its starting offensive tackles due to the virus, the Owls were limited to 234 yards of offense.

NO. 25 COASTAL CAR0LINA 28, GEORGIA SOUTHERN 14

CONWAY, S.C. (AP) — Backup quarterback Fred Payton three three touchdown passes and Coastal Carolina won its first game as a ranked team with a victory over Georgia Southern.

The Chanticleers (5-0, 3-0 Sun Belt) played without starting passer Grayson McCall, who has an upper-body injury. Payton threw a 24-yard TD pass to running back C.J. Marable with 8:53 remaining to break tie.

Georgia Southern dropped to 3-2 overall and 1-2 in the Sun Belt.

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