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By The Associated Press

The Latest on Week 3 in the NFL (all times EDT):

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2:55 p.m.

Bears star edge rusher Khalil Mack has returned against the Browns after missing most of the first half with a foot injury — and he’s already made another sack.

Mack recorded an early sack on Baker Mayfield, but left a short time later.

He returned from the locker room after being treated and stood on the sideline for the remainder of the first half.

Mack jogged onto the sideline before the third quarter started. He was handed his helmet and returned to the field for Cleveland’s first possession.

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2:55 p.m.

Pro Bowl wide receiver A.J. Brown will not return to the Titans’ game with Indianapolis.

The Titans wide receiver came out of the locker room at halftime wearing shorts and a T-shirt after hurting his hamstring early in the game Sunday. He initially was ruled questionable.

Colts All Pro left guard Quenton Nelson has been ruled out after hurting his right ankle in the second quarter. He has been replaced by Chris Reed.

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2:45 p.m.

Arizona’s Matt Prater attempted what would have been an NFL-record, 68-yard field goal at the end of the half at Jacksonville and it ended up leading to an NFL-record-tying 109-yard touchdown for the Jaguars.

Jamal Agnew, who returned a kickoff 102 yards in a loss to Denver last week, caught the short kick 9 yards deep and returned it the other way for a score and a 13-7 lead at the break.

Agnew broke one tackle – tight end Demetrius Harris had his shirttail — and then found a wall of blockers along the left sideline.

It was the NFL’s first “Kick Six” since San Diego’s Antonio Cromartie did it at Minnesota on Nov. 4, 2007.

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2:45 p.m.

Carson Wentz is playing with his sprained ankles. Luckily for the Indianapolis Colts, they have a pair of interceptions off Ryan Tannehill to set up their only points of the game.

The Colts pulled within 14-10 of the Tennessee Titans after Kenny Moore II picked off a pass that went off receiver Chester Rogers. His return set up a 43-yard field goal by Rodrigo Blankenship as the first half expired.

Wentz is 7 of 12 for 67 yards and has been sacked once with his All-Pro left guard Quenton Nelson questionable to return after being carted to the locker room from the sideline with an injured right ankle.

Tannehill is 10 of 17 for 129 yards and two touchdowns. The Titans are outgaining the Colts 213-102 and have held the ball for more than 19 minutes of the first half.

— By Teresa M. Walker reporting from Nashville, Tennessee.

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2:45 p.m.

Bears rookie quarterback Justin Fields is being treated roughly by the Browns in his first NFL start.

Fields was sacked four times by Cleveland in the first half with star defensive end Myles Garrett being credited with 2 ½ sacks.

Fields is starting in place of veteran Andy Dalton, who suffered a bruised knee last week.

The Bears have struggled to get anything going on offense. They were outgained 224-41 in the first half and got only two first downs to Cleveland’s 17.

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2:30 p.m.

The New York Giants lost three starters in the first half of their game against the Atlanta Falcons on Sunday at MetLife Stadium.

Inside linebacker Blake Martinez, their leading tackler, went down with a knee injury on the opening series.

Wide receivers Darius Slayton and Sterling Shepard left the game with hamstring injuries.

The Falcons lead the Giants 7-6 late at halftime.

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2:15 p.m.

The Buffalo Bills have capitalized on a pair of Washington Football Team turnovers — a Logan Thomas fumble and Taylor Heinicke interception — to build a 21-7 lead just over 5 minutes into the second quarter. Buffalo has scored on three of its first four possessions, and were stopped only on a failed fourth-and-2 attempt at Washington’s 35.

Jordan Poyer’s interception of Heinicke’s pass led to Josh Allen throwing his third TD pass, a 7-yarder to put Buffalo up 21-0.

Allen has now upped his career total to 99 offensive TDs, including rushing and one receiving.

Washington responded with a 73-yard TD pass to Antonio Gibson. It was the second longest TD by a running back in Washington franchise history and marked the first points Buffalo has allowed in the first half this season.

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2:05 p.m.

The Patriots lost a key cog of their offense after running back James White was carted off the field early in the second quarter with a hip injury. The team says he is out for the remainder of the game.

White was being tackled along the sideline by Saints linebacker Demario Davis after a 6-yard run with 11:34 remaining in the quarter when he landed awkwardly on his knees.

White remained on his back and was attended to by the training staff before the cart was called out.

Nearly all of White’s teammates came by to pat him on the shoulder before the cart drove to the locker room.

— Kyle Hightower, reporting from Foxborough, Mass.

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2 p.m.

The Chiefs have turned the ball over on each of their first three possessions against the Los Angeles Chargers, and five of their last six going back to last Sunday night’s loss in Baltimore.

That includes a fumble by Clyde Edwards-Helaire that prevented Kansas City from kicking a potential winning field goal against the Ravens.

Edwards-Helaire had another fumble against the Chargers. The Chiefs also got a pass from Patrick Mahomes intercepted when it bounced off Marcus Kemp and was caught by the Chargers’ Asante Samuel Jr., and Demarcus Robinson coughed up the ball when he hauled in a reception to end another drive.

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2 p.m.

Colts All-Pro left guard Quenton Nelson is questionable to return against the Tennessee Titans after being carted to the locker room.

Nelson had someone roll up on his right ankle on a third-and-1 run by Jonathan Taylor early in the second quarter. He stayed on the ground for a couple minutes before walking to the sideline slowly. Nelson was on the sideline before being taken to the locker room. He missed three weeks of training camp with injuries.

Chris Reed replaced Nelson, and the Colts finished the drive with a touchdown to tie it up at 7.

Carson Wentz started for Indianapolis, completing five of his first nine passes for 45 yards.

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1:55 p.m.

Chicago Bears star edge pass rusher Khalil Mack has gone to the locker room with a foot injury during Sunday’s game against the Browns.

Mack sacked Cleveland quarterback Baker Mayfield for an 11-yard loss late in the first quarter. It’s unclear when Mack got hurt.

The Bears said Mack’s return is questionable. One of the league’s best defensive players, Mack is a six-time Pro Bowler and the 2016 defensive player of the year.

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1:45 p.m.

The Indianapolis Colts will be without defensive end Kwity Paye for the rest of Sunday’s game against Tennessee.

Paye hurt a hamstring in the first quarter and the Colts say he won’t return to the game.

Tennessee Pro Bowl wide receiver A.J. Brown also hurt a hamstring. He missed the end of the Titans’ second drive and tested his legs on the sideline before being ruled questionable to return.

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1:30 p.m.

Saints starting left tackle Terron Armstead was treated on the field and then walked off the field with trainers favoring his left arm in the first quarter of New Orleans’ game at New England.

Armstead appeared to be hurt when his teammate, running back Tony Jones Jr., ran into his arm while trying to help him ward off a Patriots edge rusher.

The Saints were already without usual starting center Erik McCoy to begin the game before also losing Armstead. Veteran tackle James Hurst entered the game in place of Armstead and the Saints marched another 43 yards for the game’s opening score on Jameis Winston’s 11-yard pass over the middle to running back Alvin Kamara.

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1:20 p.m.

The New York Giants say inside linebacker Blake Martinez, who led the team in tackles last season, is out for the remainder of today’s game against the Atlanta Falcons with a knee injury.

Martinez had to be helped off the field less than two minutes into the game after trying to make a tackle. He walked slowly off the field with his arms around the shoulders of trainers.

In 2020, Martinez made 151 combined tackles, with three sacks, nine tackles for losses and six QB hits.

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1:15 p.m.

New York Giants inside linebacker Blake Martinez, who led the team in tackles last season, had to be helped off the field less than two minutes into the game against the Atlanta Falcons.

He appeared to injure his right foot or lower leg trying to make a tackle. He walked slowly off the field with his arms around the shoulders of trainers.

In 2020, Martinez made 151 combined tackles, with three sacks, nine tackles for losses and six QB hits.

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1:04 p.m.

The New Orleans Saints defense has two top defensive backs returning to the lineup against New England and rookie Patriots quarterback Mac Jones.

Cornerback Marshon Lattimore and nickel back C.J. Gardner-Johnson are both active after missing last Sunday’s 26-7 loss at Carolina.

Lattimore is New Orleans top defensive back. He was the 2017 defensive rookie of the year in his first season out of Ohio State and has been named to multiple Pro Bowls. On the same day New Orleans defeated Green Bay in Week 1, Lattimore agreed to a five-year extension worth nearly $100 million. But Lattimore also injured his hand in that game.

Gardner-Johnson is coming back from an knee injury.

The game also marks the first time these teams have matched up without Tom Brady and Drew Brees at QB since 2005.

The Patriots’ Jones completed 22 of 30 passes for 186 yards in New England’s Week 2 triumph over the New York Jets.

Jameis Winston starts at QB for New Orleans after one of his worst career outings last week.

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12:45 p.m.

Colts quarterback Carson Wentz has warmed up and appears to be moving well despite being questionable with sprained ankles for Indianapolis’ AFC South showdown with the Tennessee Titans.

With his right ankle heavily taped, Wentz moved around and threw passes in warmups and was subsequently listed as active for the game. He then finished warmups with the whole offense before heading to the locker room.

The Colts’ quarterback couldn’t finish last week’s loss to the Los Angeles Rams after spraining his right ankle. He already has been sacked six times and been hit 21 times. And Wentz will be without right tackle Braden Smith missing a second straight game with an injured foot and thumb.

The Titans have five sacks through two games.

— By Teresa M. Walker reporting from Nashville, Tennessee.

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12:20 p.m.

The Steelers will be without both of their starting outside linebackers against Cincinnati.

All-Pro T.J. Watt and second-year man Alex Highsmith are both battling groin injuries suffered in a loss last week to Las Vegas. Melvin Ingram, who signed in July after nine seasons with the Chargers, and Jamir Jones will start in place of Watt and Highsmith.

Pittsburgh will also be without leading receiver Diontae Johnson, who is out after injuring his knee on the final play against the Raiders. James Washington will move up the depth chart in Johnson’s absence.

The Bengals will be without wide receiver Tee Higgins.

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12:12 p.m.

OBJ is back.

Browns wide receiver Odell Beckham Jr. warmed up for his first game since undergoing knee surgery with a tribute to injured teammate Jarvis Landry.

Beckham sported gold-colored headphones and a “Juice Landry” T-shirt, a nod to his close friend and former LSU teammate who is on injured reserve with a sprained knee.

Beckham is playing for the first time Sunday since suffering a torn knee ligament on Oct. 25 at Cincinnati. The speedy Beckham made a quicker-than-expected recovery from surgery and was cleared to play after making it through practice this week.

OBJ’s return gives quarterback Baker Mayfield a deep threat against the Bears.

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12:05 p.m.

Seven teams entered Week 3 without a loss and six of them play on Sunday, highlighted by the defending Super Bowl champion Tampa Bay Buccaneers visiting the Los Angeles Rams in a late afternoon matchup.

Arizona is the lone unbeaten playing in one of Sunday’s early games as they visit the winless Jacksonville Jaguars. Fellow unbeatens Denver and Las Vegas play in the late afternoon slot with San Francisco kicking off in the night game. The Broncos host the winless Jets while the Raiders host the 1-1 Dolphins. The 49ers host the 1-1 Packers.

Carolina has Sunday off after improving to 3-0 with a victory over Houston on Thursday night.

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